Skip to main content

Maternal DDT exposure associated with autism?

A new study suggests exposure to residues persisting in the environment from pesticides banned fifty years ago is associated with autism.

The new study provides the first biomarker-based evidence in humans that maternal exposure to DDT residues in the food chain may increase the risk of autism in their children.

DDTs (organochlorines) were widely banned as pesticides from the late 1970s,  but residues persist in the food chain.



These persistent organic pollutants can be transferred from the mother across the placenta to the fetus, resulting in fetal blood concentrations ranging from 30% to 50% of levels found in maternal blood.  

The investigation,  published online in the American Journal of Psychiatry, was derived from the Finnish Prenatal Study of Autism, a large national birth cohort with maternal serum specimens from early pregnancy tested for levels of the organochlorine DDT (dichlorodiphenyl-trichloroethane) and its metabolite DDE (dichlorodiphenyl-dichloroethylene).

Low birthweight and poor cognitive development

Maternal exposure to DDT and DDE is associated with both premature birth and low birthweight.  It is also associated with adverse childhood neurocognitive outcomes, including autistic spectrum.

Autism is a complex neurodevelopment disorder characterised by impaired language, disrupted social interactions, and stereotyped behaviours and interests.  

In this study DDE levels were significantly increased in mothers of children with autism compared with mothers of those without autism.  

The authors of the study say
This study has potential implications for the prevention of autism and may provide a better understanding of its pathogenesis.
The authors also say that although there seems to be a link between autism and DDT exposure, the overall risk of having a child with the disorder is low and further research is needed to establish a clear link.  




Comments

Popular posts from this blog

Palm Oil production killing the planet

Bad trade and bad products are killing our planet. We have said this before on The Thin End. There is no better example than that of palm oil. It is used ubiquitously in so many products, and its production is a major factor destroying rainforests and threatening precious species.

Demand for palm oil is 'skyrocketing worldwide'. It is used in packaging and in so much of our snack foods, cookies, crackers, chocolate products, instant noodles, cereals, and doughnuts, and the list goes on.
Bad for the planet So, why is this so bad for the planet?

The oil is extracted from the fruit of the oil palms native to Africa. It is now grown primarily in Indonesia and Malaysia, but is also expanding across Central and West Africa and Latin America.

Palm oil production is now one of the world's leading causes of rainforest destruction, and this is impacting adversely some of the world's most culturally and biologically diverse ecosystems. Irreplaceable wildlife species like t…

Nicotine exposure in pregnancy linked to cot death

Nicotine exposure during pregnancy, whether from smoking cigarettes, or nicotine patches and e-cigarettes, increases risk of sudden infant death syndrome – sometimes known as “cot death” – according to new research published in The Journal of Physiology.

Sudden infant death syndrome (SIDS) is the sudden and unexpected death of an infant under 12 months of age occuring typically while sleeping. Failure of auto resuscitation, the ability to recover normal heart rate and breathing following gasping caused by lack of oxygen in the brain, has been recorded in human SIDS cases.



Smoking increases risk for SIDS Over the last decade, use of cigarettes has declined significantly, however, over 10% of pregnant women still smoke during pregnancy. Over recent years nicotine replacement therapies, such as nicotine patches or e-cigarettes, have been prescribed to women who wish to quit smoking during their pregnancy. However, nicotine replacement therapies may not protect infants from SIDS. 
With inc…

Maternal depression can impact child mental and physical health

Maternal depression has been repeatedly linked with negative childhood outcomes, including increased psychopathology.  Now, a new study shows that depression in mothers may impact on their children's stress levels,  as well as their physical and mental well-being throughout life.

In the study, published in the journal  Depression & Anxiety,  the researchers followed 125 children from birth to 10 years.

At 10 years old, the mothers’ and children’s cortisol (CT) and secretory immunoglobulin (s-IgA)—markers of stress and the immune system (see below)—were measured, and mother-child interaction were observed.
Psychiatric assessment  The mothers and children also had psychiatric diagnoses, and the children's externalising and internalising symptoms were reported.



Internalising disorders include depression, withdrawal, anxiety, and loneliness. They are often how we 'feel inside', such as  anger, pain, fear or hurt, but may not show it.  In contrast, externalising symptom…